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Tuesday, July 21, 2020 | History

4 edition of Ribavirin, a broad spectrum antiviral agent found in the catalog.

Ribavirin, a broad spectrum antiviral agent

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  • 11 Currently reading

Published by Academic Press in New York .
Written in English

    Subjects:
  • Virus diseases -- Chemotherapy -- Congresses.,
  • Ribavirin -- Testing -- Congresses.,
  • Ribonucleosides -- Congresses.,
  • Antiviral agents -- Congresses.

  • Edition Notes

    Statementedited by Roberts A. Smith, William Kirkpatrick.
    ContributionsSmith, Roberts Angus, 1928-, Kirkpatrick, William.
    Classifications
    LC ClassificationsRC114.5 .R5
    The Physical Object
    Paginationxiii, 237 p. :
    Number of Pages237
    ID Numbers
    Open LibraryOL4100684M
    ISBN 100126523509
    LC Control Number80015115

    Ribavirin (ICN) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. In Vitro Treatment of LPS-stimulated microglia with 5, 10 and 20 μM Ribavirin (ICN) induces reduction of NO 2 levels for 43% (p . Abstract. Ribavirin (l-β-D-ribofuranosyl-l,2,4-triazolecarboxamide) is a broad spectrum viral chemotherapeutic agent, demonstrating antiviral activity against a large number of both DNA-and RNA-containing viruses.

      Triple antiviral therapy with interferon beta-1b and ribavirin looks promising for mild to moderate infections. Merimepodib (ViralClear Pharmaceuticals): an orally-administered broad spectrum.   Antiviral compounds that increase the resistance of host tissues represent an attractive class of therapeutic. Here, we show that squalamine, a compound previously isolated from the tissues of the dogfish shark (Squalus acanthias) and the sea lamprey (Petromyzon marinus), exhibits broad-spectrum antiviral activity against human pathogens, which were .

    List of Antiviral Drugs Antiviral Use Type Year Abacavir: HIV: Acyclovir (): Herpes Simplex: Adefovir: Hepatitis B: Amantadine: Influenza: Ampligen: Avian Influenza. Ribavirin is an important broad-spectrum antiviral drug. However, its utilization can be limited by its potential to cause hemolytic anemia as well as its variability in dosing levels and efficacy outcomes. To overcome these issues, we report on a new alkoxyalkylphosphodiester prodrug of ribavirin .


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Ribavirin, a broad spectrum antiviral agent Download PDF EPUB FB2

Ribavirin is in fact a broad-spectrum antiviral agent that inhibits a wide range of RNA and DNA viruses. The mechanism for the antiviral activity of ribavirin is unclear and may differ for different types of viruses.

However, it is generally thought that ribavirin therapy alters cellular nucleotide Ribavirin, thereby affecting viral mRNA synthesis.

Ribavirin, a broad spectrum antiviral agent. [Roberts Angus Smith; William Kirkpatrick;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Book: All Authors / Contributors: Roberts Angus Smith; William Kirkpatrick.

Find more information about: ISBN: Conference proceedings; Book: Ribavirin: a broad spectrum antiviral agent. + pp. Abstract: This volume contains 17 papers presented at a symposium on ribavirin ribavirin Subject Category: Chemicals and Chemical GroupsCited by: In book: RIBAVIRIN: A Broad Spectrum Antiviral Agent, Edition: First, Chapter: 1, Publisher: Academic Press, Inc., Editors: Roberts A.

Smith; William Kirkpatrick, pp Ribavirin is a very broad-spectrum virustatic antiviral agent, first synthesised in It is characterised by low toxicity apart from reversible anaemia, usually mild. Its Cited by: Both VX and ribavirin demonstrated additivity when coapplied with IFN-alpha, with VX again being the more potent in this combination.

These data are supportive of the hypothesis that VX, like ribavirin, is a broad-spectrum antiviral agent. Ribavirin, 1-beta-D-ribofuranosyl-1,2,4-triazolecarboxyamide (Virazole; Viratek, Inc., Covina, Calif.), has a broad spectrum of antiviral activity.

However, the study of the absorption, metabolism, and excretion of this compound has been limited by the lack of an appropriate assay for ribavirin and its metabolites. Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice. Antimicrob Agents Chemother.

Apr; 17 (4)– [PMC free article] Witkowski JT, Robins RK, Sidwell RW, Simon LN. Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazolecarboxamide and related nucleosides.

The ribonucleoside analog ribavirin (1-β-D-ribofuranosyl-1,2,4-triazolecarboxamide) is also known to show broad-spectrum antiviral activity and is used in combination with interferon-α to treat hepatitis C virus infection (Crotty et al., ; Sidwell et al., ).

To that end ribavirin, a broad spectrum antiviral agent which is licensed for the treatment of hepatitis C, is often used off-label to treat patients diagnosed with LF. Although ribavirin therapy has been shown to reduce the morbidity and mortality associated with LF, its limited efficacy is reliant on treatment initiation within 6 days of.

The broad spectrum antiviral agent ribavirin inhibits capping of mRNA. Biochem Biophys Res Commun. Aug 13; 89 (3)– Hall CB, Walsh EE, Hruska JF, Betts RF, Hall WJ. Ribavirin treatment of experimental respiratory syncytial viral infection. A controlled double-blind study in young adults. JAMA.

Antiviral Research, 7 () Elsevier AVR Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro Carmen Gil-Ferndez' and Erik De Clercq2 'Centro de Investigaciones Biolicas, Consejo Superior de Investigaciones Cienticas, VelazquezMadridSpain, and.

@article{osti_, title = {Broad spectrum antiviral agent ribavirin inhibits capping of mRNA}, author = {Goswami, B B and Borek, E and Sharma, O K and Fujitaki, J and Smith, R A}, abstractNote = {Ribavirin (betaD-ribofuranosyl-1,2,4-triazolecarboxamide) is a broad spectrum antiviral substance active against a wide range of both DNA and RNA viruses.

In view of its broad-spectrum antiviral activity, treatment with ribavirin was initiated empirically very early after the recognition of the SARS outbreak.

Ribavirin is a synthetic nucleoside antiviral agent with inhibitory activity against both DNA and RNA viruses [ 2 ]. The most successful ribavirin derivative to date is the 3-carboxamidine derivative of the parent 3-carboxamide, first reported in by J.

Witkowski et al., and now called taribavirin (former names viramidine and ribamidine).This drug shows a similar spectrum of antiviral activity to ribavirin, which is not surprising as it is now known to be a pro-drug for ribavirin.

A counterpoint to this is the “one drug, multiple viruses” paradigm, which came with the discovery of broad-spectrum antiviral agents (BSAAs), small-molecules that inhibit a wide range of human viruses (Bekerman and Einav,de Clercq and Montgomery,Debing et al.,Ianevski et al.,Rada and Dragun,Sidwell et al.

The ribonucleoside analog ribavirin (1-beta-D-ribofuranosyl-1,2, 4-triazolecarboxamide) shows antiviral activity against a variety of RNA viruses and is used in combination with interferon-alpha to treat hepatitis C virus infection.

Here we show in vitro use of ribavirin Cited by: The broad spectrum antiviral agent ribavirin inhibits capping of mRNA. Biochem. Biophys. Res. Commun. 89, – (). CAS Article Google Scholar Eriksson, B. viral class pathogens, will make broad spectrum antiviral agent development difficult.

However, as many antiviral agents might be amenable to repurposing and some (favipiravir, ribavirin, cidofovir, and brincidofovir) have already shown broad-spectrum properties, the task is not impossible. To this end, a program to test current commercially avail.

Ribavirin is a very broad-spectrum virustatic antiviral agent, first synthesised in It is characterised by low toxicity apart from reversible anaemia, usually mild.

Its multiple mechanisms of action mean that viral resistance rarely develops. It can be administered orally, intravenously, or via a nebuliser. To that end ribavirin, a broad spectrum antiviral agent which is licensed for the treatment of hepatitis C, is often used off-label to treat patients diagnosed with LF.

Introduction. Ribavirin, a guanosine nucleoside analog, is a broad-spectrum antiviral that targets a variety of RNA and DNA viruses (Sidwell et al., ).Ribavirin is used clinically against hemorrhagic fever virus (Andrei and De Clercq, ), respiratory syncytial virus (Krilov, ), and with pegylated interferon to treat hepatitis C virus (HCV) infection.

Core tip: Ribavirin plays a crucial role when associated with peginterferon, preventing relapses and breakthroughs and doubling the support vector regression rate.

Its antiviral effect is weak and ribavirin could enhance the response of interferon-stimulated genes in the combination. Ribavirin is still useful in the era of approved new direct acting antiviral agents .